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Visible Light and pH Responsive Polymer‐Coated Mesoporous Silica Nanohybrids for Controlled Release
Author(s) -
Wang Guojie,
Dong Jie,
Yuan Tingting,
Zhang Juchen,
Wang Lei,
Wang Hao
Publication year - 2016
Publication title -
macromolecular bioscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 105
eISSN - 1616-5195
pISSN - 1616-5187
DOI - 10.1002/mabi.201600008
Subject(s) - mesoporous silica , visible spectrum , methacrylate , controlled release , nanopore , polymer , nanoparticle , chemistry , drug delivery , mesoporous material , nanotechnology , drug carrier , chemical engineering , materials science , organic chemistry , polymerization , catalysis , optoelectronics , engineering
A visible light and pH responsive anticancer drug delivery system based on polymer‐coated mesoporous silica nanoparticles (MSNs) has been developed. Perylene‐functionalized poly(dimethylaminoethyl methacrylates) sensitive to visible light and pH are electrostatically attached on the surface of MSNs to seal the nanopores. Stimulation of visible light and acid can unseal the nanopores to induce controlled drug release from the MSNs. More interestingly, the release can be enhanced under the combined stimulation of the dual‐stimuli. The synergistic effect of visible light and acid stimulation on the efficient release of anticancer drugs from the nanohybrids endows the system with great potential for cancer therapy.