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Cover Picture: Macromol. Biosci. 6/2015
Author(s) -
Rajesh Krishnan G.,
Cheah Calvin,
Sarkar Debanjan
Publication year - 2015
Publication title -
macromolecular bioscience
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 0.924
H-Index - 105
eISSN - 1616-5195
pISSN - 1616-5187
DOI - 10.1002/mabi.201570019
Subject(s) - self healing hydrogels , chondrogenesis , polyethylene glycol , tissue engineering , stem cell , chemistry , mesenchymal stem cell , biophysics , front cover , nanotechnology , polymer science , cover (algebra) , polymer chemistry , materials science , cell , biomedical engineering , microbiology and biotechnology , biochemistry , biology , medicine , mechanical engineering , engineering
Front Cover: On page 747 , G. Rajesh Krishnan, C. Cheah, and D. Sarkar show that physicochemical and mechanomorphological character of polyethylene glycol (PEG) hydrogel are modulated by a hybrid crosslinking mechanism where physical crosslinks are induced by hydrophobic selfassembling domains and chemical crosslinks are formed through photopolymerization. These hydrogels enable aggregation and organization of mesenchymal stem cells to control their functional state in 3D microenvironment. Enhanced aggregation of stem cells induced chondrogenesis by promoting deposition of chondrogenic matrix. Thus, cross‐linking engineering of PEG hydrogel provides an effective tool to control stem cell fate.