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Solution Behavior of Amphiphilic Glycodendrimers with a Rod‐Like Core
Author(s) -
Ordanini Stefania,
Zanchetta Giuliano,
Porkolab Vanessa,
Ebel Christine,
Fieschi Franck,
Guzzetti Ileana,
Potenza Donatella,
Palmioli Alessandro,
Podlipnik Črtomir,
Meroni Daniela,
Bernardi Anna
Publication year - 2016
Publication title -
macromolecular bioscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 105
eISSN - 1616-5195
pISSN - 1616-5187
DOI - 10.1002/mabi.201500452
Subject(s) - amphiphile , dendrimer , chemistry , dynamic light scattering , monomer , transmission electron microscopy , dissolution , hydrodynamic radius , polymer , chemical engineering , polymer chemistry , nanotechnology , copolymer , organic chemistry , nanoparticle , materials science , engineering
Glycodendrimers based on aromatic cores have an amphiphilic character and have been reported to generate supramolecuar assemblies in water. A new group of glycodendrimers with an aromatic rod‐like core were recently described as potent antagonists of DC‐SIGN‐mediated viral infections. A full characterization of the aggregation properties of these materials is presented here. The results show that these compounds exist mostly as monomers in water solution, in dynamic equilibrium with small aggregates (dimers or trimers). Larger aggregates observed by dynamic light scattering and transmission Electron Microscopy for some of the dendrimers are found to be portions of materials not fully solubilized and can be removed either by optimizing the dissolution protocol or by centrifugation of the samples.