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Reactive Oxygen Species (ROS) Responsive Polymers for Biomedical Applications
Author(s) -
Xu Qinghua,
He Chaoliang,
Xiao Chunsheng,
Chen Xuesi
Publication year - 2016
Publication title -
macromolecular bioscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 105
eISSN - 1616-5195
pISSN - 1616-5187
DOI - 10.1002/mabi.201500440
Subject(s) - reactive oxygen species , oxidative stress , cell , drug delivery , chemistry , nanotechnology , inflammation , microbiology and biotechnology , biology , materials science , biochemistry , immunology
Reactive oxygen species (ROS) play important roles in cell signaling pathways, while increased production of ROS may disrupt cellular homeostasis, giving rise to oxidative stress and a series of diseases. Utilizing these cell‐generated species as triggers for selective tuning polymer structures and properties represents a promising methodology for disease diagnosis and treatment. Recently, significant progress has been made in fabricating biomaterials including nanoparticles and macroscopic networks to interact with this dynamic physiological condition. These ROS‐responsive platforms have shown potential in a range of biomedical applications, such as cancer targeted drug delivery systems, cell therapy platforms for inflammation related disease, and so on.