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Gelatin Nanoparticles with Enhanced Affinity for Calcium Phosphate
Author(s) -
Farbod Kambiz,
Diba Mani,
Zinkevich Tatiana,
Schmidt Stephan,
Harrington Matthew J.,
Kentgens Arno P. M.,
Leeuwenburgh Sander C. G.
Publication year - 2016
Publication title -
macromolecular bioscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 105
eISSN - 1616-5195
pISSN - 1616-5187
DOI - 10.1002/mabi.201500414
Subject(s) - gelatin , glutaraldehyde , surface modification , nanoparticle , drug delivery , chemistry , kinetics , drug carrier , biocompatible material , chemical engineering , nanotechnology , materials science , biophysics , biomedical engineering , biochemistry , chromatography , organic chemistry , physics , quantum mechanics , engineering , biology , medicine
Gelatin nanoparticles can be tuned with respect to their drug loading efficiency, degradation rate, and release kinetics, which renders these drug carriers highly suitable for a wide variety of biomedical applications. The ease of functionalization has rendered gelatin an interesting candidate material to introduce specific motifs for selective targeting to specific organs, but gelatin nanoparticles have not yet been modified to increase their affinity to mineralized tissue. By means of conjugating bone‐targeting alendronate to biocompatible gelatin nanoparticles, a simple method is developed for the preparation of gelatin nanoparticles which exhibit strong affinity to mineralized surfaces. It has been shown that the degree of alendronate functionalization can be tuned by controlling the glutaraldehyde crosslinking density, the molar ratio between alendronate and glutaraldehyde, as well as the pH of the conjugation reaction. Moreover, it has been shown that the affinity of gelatin nanoparticles to calcium phosphate increases considerably upon functionalization with alendronate. In summary, gelatin nanoparticles have been developed, which exhibit great potential for use in bone‐specific drug delivery and regenerative medicine.