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Recent Strategies in Tissue Engineering for Guided Peripheral Nerve Regeneration
Author(s) -
Belanger Kayla,
Dinis Tony M.,
Taourirt Sami,
Vidal Guillaume,
Kaplan David L.,
Egles Christopher
Publication year - 2016
Publication title -
macromolecular bioscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 105
eISSN - 1616-5195
pISSN - 1616-5187
DOI - 10.1002/mabi.201500367
Subject(s) - regeneration (biology) , peripheral nerve , tissue engineering , regenerative medicine , biomedical engineering , nerve repair , computer science , anatomy , medicine , biology , stem cell , microbiology and biotechnology
The repair of large crushed or sectioned segments of peripheral nerves remains a challenge in regenerative medicine due to the complexity of the biological environment and the lack of proper biomaterials and architecture to foster reconstruction. Traditionally such reconstruction is only achieved by using fresh human tissue as a surrogate for the absence of the nerve. However, recent focus in the field has been on new polymer structures and specific biofunctionalization to achieve the goal of peripheral nerve regeneration by developing artificial nerve prostheses. This review presents various tested approaches as well their effectiveness for nerve regrowth and functional recovery.