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Cellularized Cellular Solids via Freeze‐Casting
Author(s) -
Christoph Sarah,
Kwiatoszynski Julien,
Coradin Thibaud,
Fernandes Francisco M.
Publication year - 2016
Publication title -
macromolecular bioscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 105
eISSN - 1616-5195
pISSN - 1616-5187
DOI - 10.1002/mabi.201500319
Subject(s) - casting , polymer science , chemistry , materials science , composite material
The elaboration of metabolically active cell‐containing materials is a decisive step toward the successful application of cell based technologies. The present work unveils a new process allowing to simultaneously encapsulate living cells and shaping cell‐containing materials into solid‐state macroporous foams with precisely controlled morphology. Our strategy is based on freeze casting, an ice templating materials processing technique that has recently emerged for the structuration of colloids into macroporous materials. Our results indicate that it is possible to combine the precise structuration of the materials with cellular metabolic activity for the model organism Saccharomyces cerevisiae .