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Synthesis of Amphiphilic Hyperbranched AIE‐active Fluorescent Organic Nanoparticles and Their Application in Biological Application
Author(s) -
Lv Qiulan,
Wang Ke,
Xu Dazhuang,
Liu Meiying,
Wan Qing,
Huang Hongye,
Liang Shangdong,
Zhang Xiaoyong,
Wei Yen
Publication year - 2016
Publication title -
macromolecular bioscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 105
eISSN - 1616-5195
pISSN - 1616-5187
DOI - 10.1002/mabi.201500256
Subject(s) - amphiphile , biocompatibility , nanotechnology , nanoparticle , aggregation induced emission , fluorescence , materials science , biological imaging , acrylate , chemistry , copolymer , polymer , organic chemistry , physics , quantum mechanics
Aggregation‐induced emission (AIE) dyes have recently attracted much attention for biomedical applications for their remarkable AIE properties. However, the hydrophobic nature of AIE dyes made them difficult to be dispersed in physiological solution and problematic for biomedical application directly. Great efforts have been made to overcome this problem, and different strategies for preparation of water dispersible AIE based nanoprobes had been explored previously. However, a facile and effective strategy is still highly desirable and of great importance for the biomedical applications of AIE dye based on nanoprobes. In this work, the fabrication of amphiphilic hyperbranched fluorescent organic nanoparticles with a core–shell structure based on an AIE dye [tetraphenylethene acrylate (TPE‐O‐E)] and a hyperbranched polyamino compound [polyethylene imine (PEI)] through Michael addition reaction is described for the first time. The AIE dye as well as the final product PEI‐TPE‐O‐E was characterized in detail by a number of techniques. To test their biomedical application potential, the cell viability as well as cell imaging properties of the PEI‐TPE‐O‐E was also examined. The results showed that the PEI‐TPE‐O‐E organic nanoparticles presented high water dispersiblity, ultrabright fluroerescence, low cytotoxicity and excellent biocompatibility, making them promising for biological imaging and gene delivery applications.