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Star‐Shaped, Biodegradable, and Elastomeric PLLA‐PEG‐POSS Hybrid Membrane With Biomineralization Activity for Guiding Bone Tissue Regeneration
Author(s) -
Xie Meihua,
Ge Juan,
Lei Bo,
Zhang Qian,
Chen Xiaofeng,
Ma Peter X.
Publication year - 2015
Publication title -
macromolecular bioscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 105
eISSN - 1616-5195
pISSN - 1616-5187
DOI - 10.1002/mabi.201500237
Subject(s) - biomineralization , biocompatibility , membrane , silsesquioxane , materials science , biodegradable polymer , ethylene glycol , regeneration (biology) , polymer , nanocomposite , tissue engineering , chemical engineering , polymer chemistry , chemistry , nanotechnology , composite material , biomedical engineering , organic chemistry , medicine , biochemistry , engineering , metallurgy , biology , microbiology and biotechnology
Multi‐armed biodegradable polymers have attracted much attention in biomedical applications, due to their special structure and properties. However, multi‐armed organic‐inorganic hybrids with high mechanical properties and biomineralization activity have not been reported yet. Here, star‐shaped poly‐L‐lactide‐poly (ethylene glycol)‐polyhedral oligomeric silsesquioxane (SPPS) hybrid membranes are fabricated for the first time for guiding bone regeneration applications by a photo‐crosslinking method using inositol as a core. SPPS demonstrates tunable mechanical properties (5.8 ± 0.2∼130 ± 23 MPa in tensile modulus, 30 ± 6%∼144 ± 13% in elongation, beyond 90% recovery), biodegradation, biomineralization activity and good osteoblast biocompatibility. These results suggest that our hybrids membrane may have promising applications in guiding bone regeneration.