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Anti‐Bioadhesive Coating Based on Easy to Make Pseudozwitterionic RAFT Block Copolymers for Blood‐Contacting Applications
Author(s) -
Nehache Sabrina,
Yeh ChinCheng,
Semsarilar Mona,
Deratani André,
Chang Yung,
Quemener Damien
Publication year - 2016
Publication title -
macromolecular bioscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 105
eISSN - 1616-5195
pISSN - 1616-5187
DOI - 10.1002/mabi.201500185
Subject(s) - copolymer , methacrylate , raft , polymer chemistry , bioadhesive , amphiphile , polymerization , monomer , chemistry , chain transfer , reversible addition−fragmentation chain transfer polymerization , styrene , polymer , materials science , methyl methacrylate , radical polymerization , organic chemistry
Amphiphilic diblock copolymer containing randomly distributed positive and negative charged monomers are synthesized using RAFT polymerization technique to be used as anti‐bioadhesion coatings for hydrophobic surfaces. Quaternized 2‐(dimethylamino) ethyl methacrylate and potassium 3‐sulfopropyl methacrylate (P[qDMAEMA‐ co ‐KSPMA]) are randomly polymerized to yield an anti‐bioadhesion block which is, in one pot, copolymerized with styrene as an anchoring block. This copolymer has demonstrated high anti‐bioadhesion properties to avoid the blood clotting in medical devices through a simple and facile approach to preparation of pseudozwitterionic copolymers.