Premium
Acid‐Sensitive Nanogels for Synergistic Chemo‐Photodynamic Therapy
Author(s) -
Chen Xiaofei,
Yao Xuemei,
Chen Li,
Chen Xuesi
Publication year - 2015
Publication title -
macromolecular bioscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 105
eISSN - 1616-5195
pISSN - 1616-5187
DOI - 10.1002/mabi.201500180
Subject(s) - photodynamic therapy , doxorubicin , drug delivery , chemistry , intracellular , cancer therapy , drug , nanotechnology , drug carrier , biophysics , chemotherapy , combinatorial chemistry , pharmacology , cancer , materials science , medicine , biochemistry , organic chemistry , biology , surgery
Herein, a novel kind of intelligent nanogels have been designed, which can spatiotemporally control the release of drug (doxorubicin) and photosensitizers (porphyrins) to combine chemo‐therapy and photodynamic therapy. Further, the fluorescing properties of porphyrins make it possible to be used as a kind of diagnostic bio‐imaging agents. In vitro release assays confirm that DOX‐loaded nanogels show obvious intracellular pH‐sensitive property. The intracellular experiments further prove that drug‐loaded nanogels has the significantly antitumor efficacy due to the combination of chemotherapy and photodynamic therapy, which made this drug delivery system hold great potential applications for further cancer treatment.