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Instructive Conductive 3D Silk Foam‐Based Bone Tissue Scaffolds Enable Electrical Stimulation of Stem Cells for Enhanced Osteogenic Differentiation
Author(s) -
Hardy John G.,
Geissler Sydney A.,
Aguilar David,
VillancioWolter Maria K.,
Mouser David J.,
Sukhavasi Rushi C.,
Cornelison R. Chase,
Tien Lee W.,
Preda R. Carmen,
Hayden Rebecca S.,
Chow Jacqueline K.,
Nguy Lindsey,
Kaplan David L.,
Schmidt Christine E.
Publication year - 2015
Publication title -
macromolecular bioscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 105
eISSN - 1616-5195
pISSN - 1616-5187
DOI - 10.1002/mabi.201500171
Subject(s) - tissue engineering , mesenchymal stem cell , silk , stem cell , biomedical engineering , stimulation , nanotechnology , bone tissue , scaffold , chemistry , materials science , microbiology and biotechnology , neuroscience , biology , engineering , composite material
Stimuli‐responsive materials enabling the behavior of the cells that reside within them to be controlled are vital for the development of instructive tissue scaffolds for tissue engineering. Herein, we describe the preparation of conductive silk foam‐based bone tissue scaffolds that enable the electrical stimulation of human mesenchymal stem cells (HMSCs) to enhance their differentiation toward osteogenic outcomes.