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Anti‐Resorptive Functions of Poly(ethylene sodium phosphate) on Human Osteoclasts
Author(s) -
Kootala Sujit,
Tokunaga Masahiro,
Hilborn Jöns,
Iwasaki Yasuhiko
Publication year - 2015
Publication title -
macromolecular bioscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 105
eISSN - 1616-5195
pISSN - 1616-5187
DOI - 10.1002/mabi.201500166
Subject(s) - chemistry , phosphate , sodium , ethylene , biophysics , biochemistry , polymer chemistry , organic chemistry , biology , catalysis
Osteoporosis involves hyperactive osteoclasts. A large number of current drugs result in side effects affecting their efficacy in the clinic. Polyphosphoesters are unique polymeric biomaterials because of their biocompatibility, biodegradability, and bone affinity. We studied the viability and ability of human osteoclasts to resorb bone when dosed with poly(ethylene sodium phosphate) (PEP·Na). This did not trigger any change in osteoblast cell viability, however the polymer diminished human osteoclasts and their ability to resorb bone at concentrations as low as 10 −4 m · mL −1 . This is the first report to validate the possibility of using polyphosphoesters for selective inhibition of human osteoclast functions, indicating its potential to be used as an effective polymer prodrug for treatment of osteoporosis.