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Synthesis and Characterization of pH‐Responsive Copolypeptides Vesicles for siRNA and Chemotherapeutic Drug Co‐Delivery
Author(s) -
Li Zhanrong,
Li Jingguo,
Huang Jinsheng,
Zhang Junjie,
Cheng Du,
Shuai Xintao
Publication year - 2015
Publication title -
macromolecular bioscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 105
eISSN - 1616-5195
pISSN - 1616-5187
DOI - 10.1002/mabi.201500161
Subject(s) - chemistry , drug delivery , vesicle , drug , drug carrier , pharmacology , biochemistry , medicine , organic chemistry , membrane
Novel diblock copolypeptides are synthesized and evaluated as a pH‐sensitive drug delivery vector for anticancer drugs and siRNA co‐delivery. The synthetic process involve the ring opening polymerization of α‐amino acid N‐carboxyanhydrides as well as aminolysis and deprotection reactions, and the structures are characterized. The copolypeptides can self‐assemble into stable vesicles at neutral pH, and disassemble in acidic endosomal/lysosomal, which shown the pH‐responsive behavior. The cell uptake results indicated that the vesicles can co‐deliver DOX and siRNA inside the same cell and exhibit a pH‐sensitive release behavior. Therefore, the novel polymeric vesicles are a promising carrier for co‐delivery anticancer drug and siRNA to overcome the drug resistance and enhance cancer treatment.