A New Hyaluronic Acid Derivative Obtained from Atom Transfer Radical Polymerization as a siRNA Vector for CD44 Receptor Tumor Targeting | Zendy

Palumbo Fabio Salvatore | Zendy; Bavuso Volpe Antonella | Zendy; Bongiovì Flavia | Zendy; Pitarresi Giovanna | Zendy; Giammona Gaetano | Zendy

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A New Hyaluronic Acid Derivative Obtained from Atom Transfer Radical Polymerization as a siRNA Vector for CD44 Receptor Tumor Targeting

Author(s) -

Palumbo Fabio Salvatore,

Bavuso Volpe Antonella,

Bongiovì Flavia,

Pitarresi Giovanna,

Giammona Gaetano

Publication year - 2015

Publication title -

macromolecular bioscience

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.924

H-Index - 105

eISSN - 1616-5195

pISSN - 1616-5187

DOI - 10.1002/mabi.201500129

Subject(s) - atom transfer radical polymerization , chemistry , polymerization , hyaluronic acid , polymer chemistry , methacrylate , radical polymerization , cationic polymerization , dynamic light scattering , cd44 , monomer , biophysics , in vitro , polymer , organic chemistry , materials science , biochemistry , nanotechnology , biology , nanoparticle , genetics

Two derivatives of hyaluronic acid (HA) have been synthesized by atom transfer radical polymerization (ATRP), starting from an ethylenediamino HA derivative (HA‐EDA) and by using diethylaminoethyl methacrylate (DEAEMA) as a monomer for polymerization. Both samples, indicated as HA‐EDA‐pDEAEMA a and b, are able to condense siRNA, as determined by gel retardation assay and resulting complexes show a size and a zeta potential value dependent on polymerization number, as determined by dynamic light scattering measurements. In vitro studies performed on HCT 116 cell line, that over express CD44 receptor, demonstrate a receptor mediated uptake of complexes, regardless of their surface charge.

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