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Dual Stimuli‐Responsive Poly(β‐amino ester) Nanoparticles for On‐Demand Burst Release
Author(s) -
Lee Jung Seok,
Deng Xiaojian,
Han Patrick,
Cheng Jianjun
Publication year - 2015
Publication title -
macromolecular bioscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 105
eISSN - 1616-5195
pISSN - 1616-5187
DOI - 10.1002/mabi.201500111
Subject(s) - chemistry , nanoparticle , controlled release , on demand , drug delivery , molecule , combinatorial chemistry , biophysics , chemical engineering , nanotechnology , organic chemistry , materials science , computer science , multimedia , engineering , biology
We designed poly(β‐amino esters) (PBAEs) bearing both UV light‐ and pH‐sensitive groups and used PBAEs to prepare nanoparticles (NPs) that can be utilized for on‐demand burst release of guest molecules in response to multiple triggers. Due to the presence of the photo‐cleavable group in each repeating unit of PBAE, rapid release of encapsulated model drug could be achieved even with exposures to low intensity UV (10 mW · cm −2 ). Especially, the burst release was further accelerated by additional UV treatments in the acidic condition showing the combinatory effect of dual stimuli. We believe these PBAE‐based NPs can potentially be used to design intelligent controlled release device and nanomedicines.