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Silver Nanoparticle Coated Bioactive Glasses – Composites with Dex/CMC Hydrogels: Characterization, Solubility, and In Vitro Biological Studies
Author(s) -
Wren Anthony W.,
Hassanzadeh Pegah,
Placek Lana M.,
Keenan Timothy J.,
Coughlan Aisling,
Boutelle Lydia R.,
Towler Mark R.
Publication year - 2015
Publication title -
macromolecular bioscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 105
eISSN - 1616-5195
pISSN - 1616-5187
DOI - 10.1002/mabi.201500109
Subject(s) - self healing hydrogels , solubility , nanoparticle , characterization (materials science) , bioactive glass , silver nanoparticle , chemistry , materials science , composite material , chemical engineering , polymer chemistry , nanotechnology , organic chemistry , engineering
Silver (Ag) coated bioactive glass particles ( Ag‐BG ) were formulated and compared to uncoated controls ( BG ) in relation to glass characterization, solubility and microbiology. X‐ray diffraction (XRD) confirmed a crystalline AgNP surface coating while ion release studies determined low Ag release (<2 mg/L). Cell culture studies presented increased cell viability (127 and 102%) with lower liquid extract (50 and 100 ml/ml) concentrations. Antibacterial testing of Ag‐BG in E. coli , S. epidermidis and S. aureus significantly reduced bacterial cell viability by 60–90%. Composites of Ag‐BG /CMC‐Dex Hydrogels were formulated and characterized. Agar diffusion testing was conducted where Ag‐BG /hydrogel composites produced the largest inhibition zones of 7 mm ( E. coli ), 5 mm ( S. aureus ) and 4 mm ( S. epidermidis ).
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