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Protein‐Resistant Biodegradable Amphiphilic Graft Copolymer Vesicles as Protein Carriers[Note a). a)The molar ratio of the copolymer in design; b)calculated ...]
Author(s) -
Wang Yupeng,
Yan Lesan,
Li Bin,
Qi Yanxin,
Xie Zhigang,
Jing Xiabin,
Chen Xuesi,
Huang Yubin
Publication year - 2015
Publication title -
macromolecular bioscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 105
eISSN - 1616-5195
pISSN - 1616-5187
DOI - 10.1002/mabi.201500096
Subject(s) - copolymer , amphiphile , vesicle , protein adsorption , ethylene glycol , peg ratio , chemistry , polymer chemistry , adsorption , membrane , chemical engineering , organic chemistry , polymer , biochemistry , finance , economics , engineering
The protein adsorption and self‐assembly behavior of biocompatible graft copolymer, poly(lactide‐co‐diazidomethyl trimethylene carbonate)‐g‐poly(ethylene glycol) [P(LA‐ co ‐DAC)‐ g ‐PEG], were systematically studied. The graft copolymers showed enhanced resistance to non‐specific protein adsorption compared with their block copolymer counterparts, indicative of the increased effect of PEG density beyond PEG length. Diverse nanostructures including vesicles can be assembled from the amphiphilic graft copolymers with well‐defined nano‐sizes. Hemoglobin (Hb), as a model protein, can be entrapped in the formed vesicles and keep the gas‐binding capacity. The reduced release rate of Hb from graft copolymer vesicles indicated the relatively stable membrane packing compared with block copolymer counterpart.