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Targeted Imaging and Chemo‐Phototherapy of Brain Cancer by a Multifunctional Drug Delivery System
Author(s) -
Hao Yongwei,
Wang Lei,
Zhao Yalin,
Meng Dehui,
Li Dong,
Li Haixia,
Zhang Bingxiang,
Shi Jinjin,
Zhang Hongling,
Zhang Zhenzhong,
Zhang Yun
Publication year - 2015
Publication title -
macromolecular bioscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 105
eISSN - 1616-5195
pISSN - 1616-5187
DOI - 10.1002/mabi.201500091
Subject(s) - indocyanine green , plga , in vivo , chemistry , glioma , brain cancer , docetaxel , drug delivery , nanoparticle , cancer research , cancer , pharmacology , in vitro , biophysics , nanotechnology , medicine , materials science , pathology , biochemistry , biology , organic chemistry , microbiology and biotechnology
Abstract The aim of this study was to develop multifunctional poly lactide‐co‐glycolide (PLGA) nanoparticles with the ability to simultaneously deliver indocyanine green (ICG) and docetaxel (DTX) to the brain by surface decoration with the brain‐targeting peptide angiopep‐2 to achieve combined chemo‐phototherapy for glioma under near‐infrared (NIR) imaging. ICG was selected as a near‐infrared imaging and phototherapy agent and DTX was employed as a chemotherapeutic agent. ICG and DTX were simultaneously incorporated into PLGA nanoparticles with higher stability. These nanoparticles were further decorated with angiopep‐2 via the outer maleimide group of 1,2‐distearoyl‐sn‐glycero‐3‐phosphoethanolamine‐ N ‐[methoxy(polyethyleneglycol)‐2000]‐maleinimide incorporated in the nanoparticles. The NIR image‐guided chemo‐phototherapy of the angiopep‐2 modified PLGA/DTX/ICG nanoparticles (ANG/PLGA/DTX/ICG NPs) not only highly induced U87MG cell death in vitro, but also efficiently prolonged the life span of the brain orthotopic U87MG glioma xenograft‐bearing mice in vivo. Thus, this study suggests that ANG/PLGA/DTX/ICG NPs have the potential for combinatorial chemotherapy and phototherapy for glioma.