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The Relationship Between Water Structure and Blood Compatibility in Poly(2‐methoxyethyl Acrylate) (PMEA) Analogues
Author(s) -
Sato Kazuhiro,
Kobayashi Shingo,
Kusakari Miho,
Watahiki Shogo,
Oikawa Masahiko,
Hoshiba Takashi,
Tanaka Masaru
Publication year - 2015
Publication title -
macromolecular bioscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 105
eISSN - 1616-5195
pISSN - 1616-5187
DOI - 10.1002/mabi.201500078
Subject(s) - thrombogenicity , chemistry , acrylate , differential scanning calorimetry , protein adsorption , polymer chemistry , adsorption , polymer , ethyl acrylate , organic chemistry , platelet , copolymer , thermodynamics , physics , immunology , biology
Six types of poly(2‐methoxyethyl acrylate) (PMEA) analogues were synthesized and the water structure in the hydrated polymers was characterized using differential scanning calorimetry (DSC). The hydrated PMEA analogues exhibited the different amounts of intermediate water. Non‐thrombogenicity evaluation was performed on PMEA analogues for platelet adhesion and protein adsorption. Platelet adhesion was suppressed on PMEA analogues. In addition, the protein adsorption and deformation were suppressed by increasing the amount of intermediate water. This study demonstrates that the amount of intermediate water might play a key role in expressing the blood compatibility of polymeric materials.