Premium
Dual‐Responsive pH and Temperature Sensitive Nanoparticles Based on Methacrylic Acid and Di(ethylene glycol) Methyl Ether Methacrylate for the Triggered Release of Drugs
Author(s) -
Khine Yee Yee,
Jiang Yanyan,
Dag Aydan,
Lu Hongxu,
Stenzel Martina H.
Publication year - 2015
Publication title -
macromolecular bioscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 105
eISSN - 1616-5195
pISSN - 1616-5187
DOI - 10.1002/mabi.201500057
Subject(s) - methacrylic acid , methacrylate , ethylene glycol , chemistry , polymer chemistry , ether , nanoparticle , methyl methacrylate , poly(methacrylic acid) , copolymer , organic chemistry , polymer , materials science , nanotechnology
A series of thermo‐and pH‐responsive poly(methyl methacrylate)‐ block ‐poly[methacrylic acid‐ co ‐di(ethylene glycol) methyl ether methacrylate] PMMA‐ b ‐P[MAA‐ co ‐DEGMA] block copolymers were synthesized by RAFT polymerization and self‐assembled into micelles. The molar ratio of MAA was altered from 0–12% in order to modulate the lower critical solution temperature (LCST) of PDEGMA. The release of the drug albendazole from the micelle was strongly dependent on the temperature and the LCST value of the polymer. Systems below the LCST released the drug slowly while increasing the temperature above the LCST or decreasing the pH value to 5 resulted in the burst‐like release of the drug. ABZ delivered in this pH‐responsive drug carrier had a higher toxicity than the free drug or the drug delivered in a non‐responsive drug carrier.