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Nanoparticle Formulation of AEA and BAEA Cellulose Carbamates Increases Biocompatibility and Antimicrobial Activity
Author(s) -
Wiegand Cornelia,
Nikolajski Melanie,
Hipler UtaChristina,
Heinze Thomas
Publication year - 2015
Publication title -
macromolecular bioscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 105
eISSN - 1616-5195
pISSN - 1616-5187
DOI - 10.1002/mabi.201500031
Subject(s) - biocompatibility , chemistry , cellulose , bacterial cellulose , chitosan , antimicrobial , moiety , cationic polymerization , nanoparticle , membrane , polymer , organic chemistry , amino acid , combinatorial chemistry , biochemistry , materials science , nanotechnology
Antimicrobially active polymers with a cationic moiety gain increasing interest in health care providing a biocompatible alternative to commonly used products. They adhere to the polyanionic bacterial surface, disrupt cell membranes and kill bacteria. An efficient path to obtain amino group‐containing cellulose is nucleophilic displacement reaction of p ‐toluenesulfonic acid ester and amines leading to 6‐deoxy‐6‐( ω ‐aminoalkyl) aminocellulose carbamates. Spherical nanoparticles of the obtained 6‐deoxy‐6‐(2‐aminoethyl) amino (AEA) and 6‐deoxy‐6‐{2‐bis[ N ′, N ′‐(2‐aminoethyl)]aminoethyl}amino (BAEA) cellulose carbamate with a size range of 80–120 nm were produced. The AEA and BAEA cellulose carbamates exhibited significant antimicrobial activity with moderate cell compatibility. Nanoparticle formulation enhanced biocompatibility.