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Optimization of Aqueous SI‐ATRP Grafting of Poly(Oligo(Ethylene Glycol) Methacrylate) Brushes from Benzyl Chloride Macroinitiator Surfaces[Note a). a)Molar percentage of VBC in feed; ...]
Author(s) -
Rodda Andrew E.,
Ercole Francesca,
Nisbet David R.,
Forsythe John S.,
Meagher Laurence
Publication year - 2015
Publication title -
macromolecular bioscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 105
eISSN - 1616-5195
pISSN - 1616-5187
DOI - 10.1002/mabi.201400512
Subject(s) - polymer chemistry , ethylene glycol , atom transfer radical polymerization , methacrylate , chemistry , styrene , aqueous solution , grafting , ether , polymerization , copolymer , organic chemistry , polymer
Poly(oligo(ethylene glycol) methacrylate) (pOEGMA) brushes were grafted via surface‐initiated atom transfer radical polymerization (SI‐ATRP) from a poly(styrene‐ co ‐vinylbenzyl chloride) macroinitiator. While bromoisobutyryl initiator groups are most commonly used for this purpose, benzyl chloride initiators may be advantageous for some applications due to superior stability. Water‐only graft solutions produced thicker brush coatings with superior low fouling properties (low protein adsorption and cell adhesion) versus mixed water/alcohol solutions. Coatings produced using 475 Da OEGMA (methyl ether terminated) further reduced non‐specific interactions compared to 360 Da OEGMA (hydroxyl terminated). Initiator density had minimal effect on low fouling properties.