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The Role of Charge Density and Hydrophobicity on the Biocidal Properties of Self‐Protonable Polymeric Materials[Note a). a)Evaluated from Equation (1); b)evaluated from Equation (2); c)evaluated ...]
Author(s) -
Matrella Simona,
Vitiello Carmela,
Mella Massimo,
Vigliotta Giovanni,
Izzo Lorella
Publication year - 2015
Publication title -
macromolecular bioscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 105
eISSN - 1616-5195
pISSN - 1616-5187
DOI - 10.1002/mabi.201400503
Subject(s) - alkyl , substituent , copolymer , ethylene glycol , isopropyl , chemistry , polymer chemistry , antimicrobial , methacrylate , surface charge , methyl methacrylate , polymer , organic chemistry
Intrinsic antimicrobial thermoplastic A(BC) n copolymers ( n = 1, 2, 4), where A was poly(ethylene glycol) (PEG), BC was a random chain of methylmethacrylate (MMA), and alkyl‐aminoethyl methacrylate (AAEMA), were synthesized and the antimicrobial activity and hemolyticity were evaluated on plaques obtained by casting as a function of the architecture, the N‐substituent groups of the AAEMAs (methyl, ethyl, isopropyl, and tert ‐butyl groups) and the hydrophobic/charge density balance. Antimicrobial effectiveness and efficiency is controlled by the surface charge density and by the influence of N‐alkyl groups on the surface morphology. Also interestingly, it is the absence of hemolitytic activity in all copolymers. In presence of Escherichia coli , the A(BC) 2 copolymer with 40% of N‐methyl groups is the most efficient, killing 91% of the bacteria already after 1.5 h.