Premium
Directed Interactions of Block Copolypept(o)ides with Mannose‐binding Receptors: PeptoMicelles Targeted to Cells of the Innate Immune System
Author(s) -
Heller Philipp,
Mohr Nicole,
Birke Alexander,
Weber Benjamin,
ReskeKunz Angelika,
Bros Matthias,
Barz Matthias
Publication year - 2015
Publication title -
macromolecular bioscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 105
eISSN - 1616-5195
pISSN - 1616-5187
DOI - 10.1002/mabi.201400417
Subject(s) - mannose , chemistry , amphiphile , block (permutation group theory) , receptor , mannose receptor , micelle , innate immune system , immune system , biophysics , biochemistry , immunology , copolymer , biology , in vitro , organic chemistry , geometry , mathematics , macrophage , aqueous solution , polymer
Core‐shell structures based on polypept(o)ides combine stealth‐like properties of the corona material polysarcosine with adjustable functionalities of the polypeptidic core. Mannose‐bearing block copolypept(o)ides (PSar‐block‐PGlu(OBn)) have been synthesized using 11‐amino‐3,6,9‐trioxa‐undecyl‐2,3,4,6‐tetra‐O‐acetyl‐O‐α‐D‐mannopyranoside as initiator in the sequential ring‐opening polymerization of α‐amino acid N‐carboxyanhydrides. These amphiphilic block copolypept(o)ides self‐assemble into multivalent PeptoMicelles and bind to mannose‐binding receptors as expressed by dendritic cells. Mannosylated micelles showed enhanced cell uptake in DC 2.4 cells and in bone marrow‐derived dendritic cells (BMDCs) and therefore appear to be a suitable platform for immune modulation.