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Glycosylated Star Polypeptides from NCA Polymerization: Selective Binding as a Function of Degree of Branching and Glycosylation
Author(s) -
Byrne Mark,
Mildner Robert,
Menzel Henning,
Heise Andreas
Publication year - 2015
Publication title -
macromolecular bioscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 105
eISSN - 1616-5195
pISSN - 1616-5187
DOI - 10.1002/mabi.201400371
Subject(s) - branching (polymer chemistry) , glycosylation , chemistry , dendrimer , degree of polymerization , polymerization , lectin , polymer chemistry , stereochemistry , biophysics , biochemistry , organic chemistry , polymer , biology
Star‐shaped polypeptides were synthesized via N‐carboxyanhydride (NCA) polymerization initiated from various generations of PPI dendrimers. Molecular weight, arm length, and arm density were readily controlled to afford a series of star‐shaped poly(glutamic acid) derivatives. Glycosylation of star‐shaped poly(glutamic acid) resulted in the formation of a diverse range of glycopolypeptide architectures with tuneable degree of sugar conjugation. The secondary structure of the branched glycopolypeptides was studied as a function of the degree glycosylation. The bioactivity of the described glycopoly‐peptides toward the lectin ConA was investigated and was shown to be architecture dependent.