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Self‐assembled Monolayers and Nanocomposite Hydrogels of Functional Nanomaterials for Tissue Engineering Applications
Author(s) -
Kehr Nermin Seda,
Atay Seda,
Ergün Bahar
Publication year - 2015
Publication title -
macromolecular bioscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 105
eISSN - 1616-5195
pISSN - 1616-5187
DOI - 10.1002/mabi.201400363
Subject(s) - self healing hydrogels , surface modification , nanotechnology , nanomaterials , tissue engineering , materials science , nanocomposite , polymer , monolayer , chemistry , polymer chemistry , biomedical engineering , composite material , medicine
In biotechnology, SAMs and NC hydrogels of functional nanomaterials are of high interest as 2D and 3D cell culture systems, respectively, to mimic natural ECM and to control cell behaviors. Advanced biotechnological approaches often use nanoscale topography together with suitable surface functionalization, as a model of ECM, to control cell behaviors and tissue formation. SAMs of NMs are effective ECM models as 2D surfaces due to their larger nanostructured surface areas which provide higher molecular density by functionalization on a planar substrate than molecular SAMs. Additionally, NC hydrogels, produced by cross‐linking of organic polymers with NMs, are excellent candidates as 3D cell culture systems owing to their optical, cell‐compatibility and the extraordinary mechanical properties.