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Thermoresponsive Self‐Assembly of Nanostructures from a Collagen‐Like Peptide‐Containing Diblock Copolymer
Author(s) -
Luo Tianzhi,
He Lirong,
Theato Patrick,
Kiick Kristi L.
Publication year - 2015
Publication title -
macromolecular bioscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 105
eISSN - 1616-5195
pISSN - 1616-5187
DOI - 10.1002/mabi.201400358
Subject(s) - lower critical solution temperature , copolymer , methacrylate , polymer chemistry , peptide , thermoresponsive polymers in chromatography , aqueous solution , chemistry , polymer , drug delivery , smart polymer , self assembly , diethylene glycol , micelle , conjugate , materials science , ethylene glycol , organic chemistry , biochemistry , high performance liquid chromatography , reversed phase chromatography , mathematical analysis , mathematics
Temperature‐triggered formation of nanostructures with distinct biological activity offers opportunities in selective modification of matrices and in drug delivery. Toward these ends, diblock polymers comprising poly(diethylene glycol methyl ether methacrylate) (PDEGMEMA) conjugated to a triple helix‐forming collagen‐like peptide were produced. Triggered by the collapse of the thermoresponsive domain above its LCST, the conjugate undergoes a reversible transition in aqueous solution to form well‐defined nanovesicles with diameters of approximately 100 nm, with a transition temperature of 37 °C. The incorporation of CLP domains in these nanostructures may offer opportunities for the selective targeting of collagen‐containing matrices.