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pH‐Responsive Single Walled Carbon Nanotube Dispersion for Target Specific Release of Doxorubicin to Cancer Cells
Author(s) -
Ghosh Moumita,
Brahmachari Sayanti,
Das Prasanta Kumar
Publication year - 2014
Publication title -
macromolecular bioscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 105
eISSN - 1616-5195
pISSN - 1616-5187
DOI - 10.1002/mabi.201400290
Subject(s) - carbon nanotube , hela , exfoliation joint , chemistry , doxorubicin , dispersion (optics) , cancer cell , biophysics , chemical engineering , nanotechnology , materials science , in vitro , cancer , biochemistry , graphene , chemotherapy , medicine , surgery , physics , engineering , optics , biology
Cholesterol‐based dipeptide carboxylates were synthesized and exploited for the pH responsive reversible dispersion and precipitation of single walled carbon nanotube (SWCNT) in water specifically at tumorogenic environmental pH (6.0–6.5). The nanohybrid showed excellent pH responsive drug release between pH range of 6.0 and 6.5. The exfoliation of SWCNTs was characterized by microscopic and spectroscopic studies. Importantly, drug‐loaded SWCNT dispersions showed better killing efficiency compared to that of the native drug and were highly efficient in selective killing of cancer cells (Hela, HepG2) with 2.5‐fold higher efficacy compared to that of normal cells (CHO, NIH3T3).