Premium
Bamboo Leaf‐Like Micro‐Nano Sheets Self‐Assembled by Block Copolymers as Wafers for Cells
Author(s) -
Zhu Wen,
Peng Bo,
Wang Jing,
Zhang Ke,
Liu Lixin,
Chen Yongming
Publication year - 2014
Publication title -
macromolecular bioscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 105
eISSN - 1616-5195
pISSN - 1616-5187
DOI - 10.1002/mabi.201400283
Subject(s) - copolymer , wafer , bamboo , nano , materials science , block (permutation group theory) , polymer science , nanotechnology , polymer chemistry , composite material , polymer , geometry , mathematics
Bamboo leaf shaped poly(ethylene oxide)‐ b ‐poly(ϵ‐caprolactone) (PEO‐ b ‐PCL) sheets were prepared via crystallization‐driven self‐assembly. By selecting an appropriate mixed solvent, the polymer sheets, with a PCL single‐crystal layer sandwiched by two PEO layers, were obtained efficiently. The morphology and structure of the sheets were characterized by microscopes and diffraction techniques. As a non‐spherical model particle, endocytosis of the sheets was investigated on RAW 264.7, U937, HUVECs, HeLa, and 293T cells. The polymer sheets, just like wafers for cells, displayed a selective internalization to different cells, which showed a potential application in accurate cell targeting drug delivery and imaging.