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A Combined Micelle and Poly(Serinol Hexamethylene Urea)‐ Co ‐Poly( N ‐Isopropylacrylamide) Reverse Thermal Gel as an Injectable Ocular Drug Delivery System
Author(s) -
Famili Amin,
Kahook Malik Y.,
Park Daewon
Publication year - 2014
Publication title -
macromolecular bioscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 105
eISSN - 1616-5195
pISSN - 1616-5187
DOI - 10.1002/mabi.201400250
Subject(s) - chemistry , micelle , poly(n isopropylacrylamide) , drug delivery , polymer chemistry , urea , triamcinolone acetonide , polymer , drug , nuclear chemistry , chromatography , organic chemistry , copolymer , pharmacology , aqueous solution , surgery , medicine
We have developed an in situ‐gelling polymer system comprised of drug‐loaded micelles encapsulated within a reverse thermal gel (RTG) as an injectable ocular drug delivery system. The RTG chemistry employs a novel poly( N ‐isopropylacrylamide) (PNIPAAm) polymer—designed to permit complete physiological clearance of the system during degradation—coupled to a poly(serinol hexamethylene urea) (PSHU) backbone, which was designed to mimic natural materials. Inclusion of drug‐loaded micelles significantly improved release kinetics of the poorly‐soluble corticosteroid triamcinolone acetonide; the combined system is projected to sustain release for approximately one year based on in vitro testing. Both the RTG and micelles were well tolerated after intravitreal injection in rats.