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Poly(anhydride‐ester) and Poly(N‐vinyl‐2‐pyrrolidone) Blends: Salicylic Acid‐Releasing Blends with Hydrogel‐Like Properties that Reduce Inflammation
Author(s) -
Ouimet Michelle A.,
Fogaça Renata,
Snyder Sabrina S.,
Sathaye Sameer,
Catalani Luiz H.,
Pochan Darrin J.,
Uhrich Kathryn E.
Publication year - 2015
Publication title -
macromolecular bioscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 105
eISSN - 1616-5195
pISSN - 1616-5187
DOI - 10.1002/mabi.201400238
Subject(s) - swelling , chemistry , salicylic acid , polymer chemistry , polymer , self healing hydrogels , 2 pyrrolidone , polymer blend , in vitro , chemical engineering , materials science , organic chemistry , copolymer , biochemistry , composite material , engineering
Polymers such as poly(N‐vinyl‐2‐pyrrolidone) (PVP) have been used to prepare hydrogels for wound dressing applications but are not inherently bioactive. For enhanced healing, PVP was blended with salicylic acid‐based poly(anhydride‐esters) (SAPAE) and shown to exhibit hydrogel properties upon swelling. In vitro release studies demonstrated that the chemically incorporated drug (SA) was released from the polymer blends over 3–4 d in contrast to 3 h, and that blends of higher PVP content displayed greater swelling values and faster SA release. The polymer blends significantly the inflammatory cytokine, TNF‐α, in vitro without negative effects.