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Stabilization of Gelatin Nanoparticles Without Crosslinking
Author(s) -
Khan Saeed Ahmad,
Schneider Marc
Publication year - 2014
Publication title -
macromolecular bioscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 105
eISSN - 1616-5195
pISSN - 1616-5187
DOI - 10.1002/mabi.201400214
Subject(s) - gelatin , nanoparticle , chemical engineering , homogenization (climate) , porosity , chemistry , morphology (biology) , polymer chemistry , nanotechnology , materials science , organic chemistry , biodiversity , ecology , engineering , biology , genetics
Gelatin nanoparticles can be stabilized by entrapping them in Eudragit E100 nanospheres. The size of the nanospheres was dependent on the homogenization speed, producing nanospheres of 433 nm (8000 rpm) and 176 nm (15000 rpm). The nanoparticle morphology was critically dependent on Eudragit E100 concentration; with 2% Eudragit E 100 nanospheres showed spherical depressions (pores) of around 90 nm on the surface. The number of porous particles decreased from 68% to 5% when Eudragit1 E 100 concentration was increased to 6%, which in turn improved gelatin entrapment from 55% to 93% respectively. Additionally, the initial burst release of gelatin was decreased from 30% to 10% respectively.