Premium
Synthesis of Functionalized Poly(ester carbonate) with Laminin‐Derived Peptide for Promoting Neurite Outgrowth of PC12 cells
Author(s) -
Xing Dongming,
Ma Lie,
Gao Changyou
Publication year - 2014
Publication title -
macromolecular bioscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 105
eISSN - 1616-5195
pISSN - 1616-5187
DOI - 10.1002/mabi.201400186
Subject(s) - maleimide , chemistry , polymer chemistry , neurite , copolymer , organic chemistry , polymer , in vitro , biochemistry
Maleimide‐functionalized poly(ester carbonate)s are synthesized by ring‐opening copolymerization of furan–maleimide functionalized trimethylene carbonate (FMTMC) with L ‐lactide and a subsequent retro Diels‐Alder reaction. The maleimide groups on poly(ester carbonate)s are amenable to Michael addition with thiol‐containing molecules such as 3‐mercapto‐1‐propanol, 2‐aminoethanethiol hydrochloride, and mercaptoacetic acid under mild conditions, enabling the formation of biodegradable materials with various functional groups (e.g., hydroxyl, amine, and carboxyl). In particular, the maleimide‐functionalized poly(ester carbonate) is clicked with a laminin‐derived peptide CQAASIKVAV. In vitro culture of PC12 cells shows that the maleimide‐functionalized polymers, especially the CQAASIKVAV‐grafted one, could support cell proliferation and neurite outgrowth. The maleimide‐functionalized poly(ester carbonate)s provide a versatile platform for diverse functionalization and have comprehensive potential in biomedical engineering.