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A Novel Crosslinked Hyaluronic Acid Nanogel for Drug Delivery
Author(s) -
Pedrosa Sílvia Santos,
Gonçalves Catarina,
David Laurent,
Gama Miguel
Publication year - 2014
Publication title -
macromolecular bioscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 105
eISSN - 1616-5195
pISSN - 1616-5187
DOI - 10.1002/mabi.201400135
Subject(s) - nanogel , conjugate , hyaluronic acid , chemistry , amphiphile , drug delivery , drug carrier , grafting , polymer chemistry , nanoparticle , conjugated system , copolymer , combinatorial chemistry , chemical engineering , biophysics , polymer , nanotechnology , organic chemistry , materials science , mathematics , biology , engineering , mathematical analysis , genetics
An amphiphilic hyaluronic acid conjugate is successfully developed based on grafting a thiolated hydrophobic molecule to the polysaccharide backbone. The engineered conjugate is capable of assembling into nanostructures once dispersed in water, with average diameter of 80.2 ± 0.4 nm ( n = 5), stable up to 6 months. The thiolated HyA conjugate is reticulated by dissulfide bond with a homofunctional crosslinker—1,4‐Bis(3‐[2‐pyridyldithio]propionamido)butane (DPDPB). The drug loading efficiency of the reticulated and non‐reticulated nanogel is accessed with two hydrophobic drugs, curcumin and simvastatin. Results suggest that crosslinked nanogel exhibit higher stability upon dilution and drug loading efficiency and proves to be a redox sensitive material. The nanogels hold great potential as stealth carriers of lipophilic drugs.