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Tailor‐Made Nanocontainers for Combined Magnetic‐Field‐Induced Release and MRI
Author(s) -
Bannwarth Markus B.,
Ebert Sandro,
Lauck Maximilian,
Ziener Ulrich,
Tomcin Stephanie,
Jakob Gerhard,
Münnemann Kerstin,
Mailänder Volker,
Musyanovych Anna,
Landfester Katharina
Publication year - 2014
Publication title -
macromolecular bioscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 105
eISSN - 1616-5195
pISSN - 1616-5187
DOI - 10.1002/mabi.201400122
Subject(s) - nanocapsules , nanoparticle , nanocarriers , superparamagnetism , materials science , nanotechnology , miniemulsion , magnetic nanoparticles , mri contrast agent , magnetic field , chemistry , chemical engineering , polymer , polymerization , magnetization , composite material , physics , quantum mechanics , engineering
The synthesis of a novel nanocapsule‐based carrier system is described, possessing a triggered release in remote‐controlled fashion upon application of an external magnetic field in combination with the possibility to use the capsules as contrast agents for magnetic resonance imaging (MRI). Therefore, polymeric nanocontainers containing a high amount of superparamagnetic MnFe 2 O 4 nanoparticles and a thermo‐degradable shell are fabricated via a miniemulsion route. The process allows the facile encapsulation of hydrophilic compounds, as demonstrated for a model dye. Release of the encapsulated dye is achieved upon application of an external alternating magnetic field. While the magnetic nanoparticles here act as heat generators to stimulate the decomposition of the shell and subsequently a release of the payload, they additionally enable the use of the nanocapsules as imaging agents for MRI. Due to the encapsulated magnetic nanoparticles, the nanocapsules possess high r 2 relaxivity values of 96–120 Hz mmol −1 , which makes them suitable for MRI. In toxicity experiments, the nanocapsules show no cell toxicity up to fairly high concentrations (600 µg mL −1 ). Due to their dual‐functionality, the nanocapsules possess high potential as nanocarriers with combined magnetic‐field‐induced release capability and as contrast agents for MRI.