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Bioreducible Polycations in Nucleic Acid Delivery: Past, Present, and Future Trends
Author(s) -
Oupický David,
Li Jing
Publication year - 2014
Publication title -
macromolecular bioscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 105
eISSN - 1616-5195
pISSN - 1616-5187
DOI - 10.1002/mabi.201400061
Subject(s) - nucleic acid , chemistry , disulfide bond , transfection , gene delivery , nanotechnology , redox , biophysics , combinatorial chemistry , biochemistry , materials science , organic chemistry , biology , gene
Polycations that are degradable by reduction of disulfide bonds are developed for applications in delivery of nucleic acids. This Feature Article surveys methods of synthesis of bioreducible polycations and discusses current understanding of the mechanism of action of bioreducible polyplexes. Emphasis is placed on the relationship between the biological redox environment and toxicity, trafficking, transfection activity, and in vivo behavior of bioreducible polycations and polyplexes.