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Glycopolymer Functionalization of Engineered Spider Silk Protein‐based Materials for Improved Cell Adhesion
Author(s) -
Hardy John G.,
Pfaff André,
LealEgaña Aldo,
Müller Axel H. E.,
Scheibel Thomas R.
Publication year - 2014
Publication title -
macromolecular bioscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 105
eISSN - 1616-5195
pISSN - 1616-5187
DOI - 10.1002/mabi.201400020
Subject(s) - spider silk , surface modification , silk , biocompatibility , adhesion , materials science , polymer science , extracellular matrix , tissue engineering , nanotechnology , cell adhesion , coating , biomaterial , chemistry , biomedical engineering , composite material , biochemistry , medicine , metallurgy
Silk protein‐based materials are promising biomaterials for application as tissue scaffolds, due to their processability, biocompatibility, and biodegradability. The preparation of films composed of an engineered spider silk protein (eADF4(C16)) and their functionalization with glycopolymers are described. The glycopolymers bind proteins found in the extracellular matrix, providing a biomimetic coating on the films that improves cell adhesion to the surfaces of engineered spider silk films. Such silk‐based materials have potential as coatings for degradable implantable devices.