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Multifunctional Poly(Vinyl Amine)s Bearing Azetidinium Groups: One Pot Preparation in Water and Antimicrobial Properties
Author(s) -
Chattopadhyay Subrata,
Heine Elisabeth Therese,
Keul Helmut,
Möller Martin
Publication year - 2014
Publication title -
macromolecular bioscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 105
eISSN - 1616-5195
pISSN - 1616-5187
DOI - 10.1002/mabi.201300576
Subject(s) - cationic polymerization , antimicrobial , chemistry , polymer , amine gas treating , polymerization , bifunctional , polymer chemistry , minimum inhibitory concentration , bacteria , organic chemistry , combinatorial chemistry , biology , genetics , catalysis
Abstract A simple, robust one pot procedure for the preparation of waterborne multifunctional poly(vinyl amine)s ( PVAm s) is presented. By post‐polymerization modification of PVAm with a bifunctional coupler and functional couplers cationic, reactive azetidinium groups, and alkyl chains are introduced in the side chains of PVAm s. The structure‐activity relations (effect of hydrophobic and cationic modifications) of these antimicrobial polymers are studied; the minimum inhibitory concentration (MIC) against both (Gram positive and Gram negative bacteria) of the library of multifunctional poly(vinyl amine)s are determined to identify the candidates with the highest efficacy. Furthermore, the hemolytic activity—the effective concentration at which 50 and 10% of red blood cells are killed (HC 50 and HC 10 )—of selected polymers is determined. The ability of the polymers prepared to differentiate between microorganisms (Gram positive and Gram negative bacteria) and mammalian cells (red blood cells) is understood by comparing MIC and HC values. Finally, as an example, the best polymer is used to prepare an antimicrobial surface.