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Chitosan‐coated Gold Nanorods for Cancer Therapy Combining Chemical and Photothermal Effects
Author(s) -
Duan Ruiping,
Zhou Zhimin,
Su Guanghao,
Liu Lingrong,
Guan Man,
Du Bo,
Zhang Qiqing
Publication year - 2014
Publication title -
macromolecular bioscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 105
eISSN - 1616-5195
pISSN - 1616-5187
DOI - 10.1002/mabi.201300563
Subject(s) - photothermal therapy , nanocarriers , chitosan , biocompatibility , photothermal effect , nanorod , chemistry , nanoparticle , doxorubicin , cytotoxicity , nanotechnology , hela , chemical modification , conjugated system , materials science , in vitro , polymer , organic chemistry , polymer chemistry , chemotherapy , biochemistry , medicine , surgery
To develop a novel type of nanoparticle for cancer therapy, gold nanorods (GNRs) are coated with chitosan (CS) derivatives to combine chemical and photothermal effects. Thiol‐modified chitosan derivatives chemically conjugated to doxorubicin (DOX) are successfully synthesized and their in vitro effect is evaluated. Functional nanocarriers (DOX‐CS‐GNR) with good biocompatibility and optical properties are prepared by conjugating chitosan derivatives to GNRs. Two types of structures with different molar ratios of chitosan derivatives and GNRs are successfully obtained. In in vitro studies, GNR‐loaded nanoparticles show low cytotoxicity and high potential for anti‐cancer effects. Under conditions of short exposure time and low light intensity, DOX‐CS‐GNR nanocarriers with a side‐by‐side structure exhibit cytoxicity against tumor cells based on a combination of chemical and photothermal therapeutic effects.