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Polyvalent Display of Monosaccharides on Ferritin Protein Cage Nanoparticles for the Recognition and Binding of Cell‐Surface Lectins
Author(s) -
Kang Young Ji,
Yang Hyun Ji,
Jeon Sangbin,
Kang YoungSun,
Do Yoonkyung,
Hong Sung You,
Kang Sebyung
Publication year - 2014
Publication title -
macromolecular bioscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 105
eISSN - 1616-5195
pISSN - 1616-5187
DOI - 10.1002/mabi.201300528
Subject(s) - monosaccharide , lectin , maleimide , chemistry , ferritin , dc sign , mannose , biochemistry , galactose , biophysics , biology , polymer chemistry , immunology , antigen , dendritic cell
Carbohydrate‐lectin interactions are important in many biological events. Endogenous cell‐surface lectins are attractive markers for the recognition and targeting. Human ferritin protein cage nanoparticles (HFPCNs) are prepared as delivery nanoplatforms and two different types of monosaccharide derivatives; maleimido group terminated‐mannopyranoside and galactopyranoside. Uniform and polyvalent displays of mannoses or galactoses on the surface of HFPCNs are achieved by using site‐specific thiol‐maleimide Michael‐type addition. Mannose‐ or galactose‐displaying HFPCNs recognize and tightly bind to DC‐SIGN or ASGP‐R lectins on the surface of the mammalian cells, DCEK or HepG2 cells.