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Shape‐Memory Effect by Specific Biodegradable Polymer Blending for Biomedical Applications
Author(s) -
Cha Kook Jin,
Lih Eugene,
Choi Jiyeon,
Joung Yoon Ki,
Ahn Dong Jun,
Han Dong Keun
Publication year - 2014
Publication title -
macromolecular bioscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 105
eISSN - 1616-5195
pISSN - 1616-5187
DOI - 10.1002/mabi.201300481
Subject(s) - biocompatibility , materials science , polymer , shape memory polymer , biodegradable polymer , glass transition , shape memory alloy , composite material , casting , plga , chemical engineering , biomedical engineering , nanotechnology , medicine , nanoparticle , engineering , metallurgy
Abstract Specific biodegradable polymers having shape‐memory properties through “polymer‐blend” method are investigated and their shape‐switching in body temperature (37 °C) is characterized. Poly( L ‐lactide‐ co ‐caprolactone) (PLCL) and poly( L ‐lactide‐ co ‐glycolide) (PLGA) are dissolved in chloroform and the films of several blending ratios of PLCL/PLGA are prepared by solvent casting. The shape‐memory properties of films are also examined using dynamic mechanical analysis (DMA). Among the blending ratios, the PLCL50/PLGA50 film shows good performance of shape‐fixity and shape‐recovery based on glass transition temperature. It displays that the degree of shape recovery is 100% at 37 °C and the shape recovery proceeds within only 15 s. In vitro biocompatibility studies are shown to have good blood compatibility and cytocompatibility for the PLCL50/PLGA50 films. It is expected that this blended biodegradable polymer can be potentially used as a material for blood‐contacting medical devices such as a self‐expended vascular polymer stents and vascular closure devices in biomedical applications.