Gold Nanoparticle Loaded Hybrid Nanofibers for Cardiogenic Differentiation of Stem Cells for Infarcted Myocardium Regeneration | Zendy

Ravichandran Rajeswari | Zendy; Sridhar Radhakrishnan | Zendy; Venugopal Jayarama Reddy | Zendy; Sundarrajan Subramanian | Zendy; Mukherjee Shayanti | Zendy; Ramakrishna Seeram | Zendy

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Gold Nanoparticle Loaded Hybrid Nanofibers for Cardiogenic Differentiation of Stem Cells for Infarcted Myocardium Regeneration

Author(s) -

Ravichandran Rajeswari,

Sridhar Radhakrishnan,

Venugopal Jayarama Reddy,

Sundarrajan Subramanian,

Mukherjee Shayanti,

Ramakrishna Seeram

Publication year - 2014

Publication title -

macromolecular bioscience

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.924

H-Index - 105

eISSN - 1616-5195

pISSN - 1616-5187

DOI - 10.1002/mabi.201300407

Subject(s) - electrospinning , regeneration (biology) , nanofiber , biomedical engineering , fourier transform infrared spectroscopy , nanoparticle , scanning electron microscope , tissue engineering , transmission electron microscopy , scaffold , materials science , chitosan , in vivo , nanotechnology , colloidal gold , self healing hydrogels , chemistry , chemical engineering , polymer chemistry , polymer , composite material , organic chemistry , medicine , microbiology and biotechnology , engineering , biology

Heart disease is the leading cause of mortality in many industrialized nations and is often related to irregularities in electrical function that can radically damage cardiac functioning. The aim of this study is to develop a novel therapeutic hybrid scaffold that can couple electrical, mechanical, and biological properties, desirable for cardiac tissue regeneration. BSA/PVA scaffolds are fabricated in the ratio 2:1 and gold nanoparticles (AuNPs) embedded scaffolds in the ratios BSA/PVA/Au of 2:1:0.1 (lower concentration) and BSA/PVA/Au of 2:1:0.4 (higher concentration) by electrospinning. The scaffolds are characterized by scanning electron microscopy (SEM), transmission electron microscopy (TEM), contact angle, Fourier transform infrared (FTIR) spectroscopy, and tensile testing to analyze the fiber morphology, AuNP distribution, hydrophilicity, surface functional groups, and mechanical properties of the scaffolds, respectively. Results show that ex vivo pretreatment of MSCs using 5‐aza and AuNPs loaded conductive nanofibrous construct could lead to enhanced cardiomyogenic differentiation and result in superior biological and functional effects on infarcted myocardium regeneration.

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