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Biodegradable, p H ‐ R esponsive Carboxymethyl Cellulose/ P oly( A crylic Acid) Hydrogels for Oral Insulin Delivery
Author(s) -
Gao Xiaoye,
Cao Yue,
Song Xiangfu,
Zhang Zhe,
Zhuang Xiuli,
He Chaoliang,
Chen Xuesi
Publication year - 2014
Publication title -
macromolecular bioscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 105
eISSN - 1616-5195
pISSN - 1616-5187
DOI - 10.1002/mabi.201300384
Subject(s) - self healing hydrogels , carboxymethyl cellulose , chemistry , bioavailability , insulin , oral administration , methyl cellulose , cellulose , polysaccharide , biochemistry , pharmacology , polymer chemistry , medicine , organic chemistry , sodium
Biodegradable and pH‐responsive carboxymethyl cellulose/poly(acrylic acid) hybrid hydrogels are synthesized. The hydrogels deswell in acidic artificial gastric fluid (AGF) but rapidly swell in neutral artificial intestinal fluid (AIF), rendering selective enzymatic degradation of the gels as well as accelerated drug release from insulin‐loaded hydrogels in AIF. Oral administration of insulin‐loaded hydrogels to streptozotocin‐induced diabetic rats leads to a continuous decline in the fasting blood glucose level within 6 h post‐administration, and the relative pharmacological availability increases more than 10 times compared to oral administration of free insulin solution. The relative bioavailability of hydrogel‐encapsulated insulin after oral administration to healthy rabbits is 6.6%.