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Fumed Silica Nanoparticle Mediated Biomimicry for Optimal Cell– M aterial Interactions for Artificial Organ Development
Author(s) -
de Mel Achala,
Ramesh Bala,
Scurr David J.,
Alexander Morgan R.,
Hamilton George,
Birchall Martin,
Seifalian Alexander M.
Publication year - 2014
Publication title -
macromolecular bioscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 105
eISSN - 1616-5195
pISSN - 1616-5187
DOI - 10.1002/mabi.201300382
Subject(s) - biomimetics , scaffold , nanotechnology , surface modification , nanocomposite , tissue engineering , extracellular matrix , biomedical engineering , nanoparticle , materials science , biomimetic materials , chemistry , engineering , biochemistry
Replacement of irreversibly damaged organs due to chronic disease, with suitable tissue engineered implants is now a familiar area of interest to clinicians and multidisciplinary scientists. Ideal tissue engineering approaches require scaffolds to be tailor made to mimic physiological environments of interest with specific surface topographical and biological properties for optimal cell‐material interactions. This study demonstrates a single‐step procedure for inducing biomimcry in a novel nanocomposite base material scaffold, to re‐create the extracellular matrix, which is required for stem cell integration and differentiation to mature cells. Fumed silica nanoparticle mediated procedure of scaffold functionalization, can be potentially adapted with multiple bioactive molecules to induce cellular biomimicry, in the development human organs. The proposed nanocomposite materials already in patients for number of implants, including world first synthetic trachea, tear ducts and vascular bypass graft.