Shear Reversible Cell/Microsphere Aggregate as an Injectable for Tissue Regeneration | Zendy

Woo Eunkyeong | Zendy; Park Honghyun | Zendy; Lee Kuen Yong | Zendy

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Shear Reversible Cell/Microsphere Aggregate as an Injectable for Tissue Regeneration

Author(s) -

Woo Eunkyeong,

Park Honghyun,

Lee Kuen Yong

Publication year - 2014

Publication title -

macromolecular bioscience

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.924

H-Index - 105

eISSN - 1616-5195

pISSN - 1616-5187

DOI - 10.1002/mabi.201300365

Subject(s) - microsphere , tissue engineering , chemistry , emulsion , regeneration (biology) , biomedical engineering , in vivo , aggregate (composite) , biophysics , chemical engineering , materials science , nanotechnology , biochemistry , microbiology and biotechnology , medicine , engineering , biology

Injectable delivery systems have been widely used in tissue engineering as they can deliver cells into the body in a minimally invasive manner. In this study, it is hypothesized that microspheres with a similar size of cells could effectively form a shear reversible aggregate in the presence of cells and the aggregate could be useful to engineer tissues. Alginate microspheres are prepared by an emulsion method, followed by modification with a peptide containing the arginine‐glycine‐aspartic acid (RGD) sequence. RGD‐modified alginate microspheres form an aggregate in the presence of chondrocytes, and the aggregation behavior is shear reversible. This cell/microsphere aggregate is useful to deliver chondrocytes into an animal model using a syringe, and effectively regenerates cartilage tissues in vivo.

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