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Cross‐linked Iron Oxide Nanoparticles for Therapeutic Engineering and in Vivo Monitoring of Mesenchymal Stem Cells in Cerebral Ischemia Model
Author(s) -
Park Ji Won,
Ku Sook Hee,
Moon HyungHo,
Lee Minhyung,
Choi Donghoon,
Yang Jaemoon,
Huh YongMin,
Jeong Ji Hoon,
Park Tae Gwan,
Mok Hyejung,
Kim Sun Hwa
Publication year - 2014
Publication title -
macromolecular bioscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 105
eISSN - 1616-5195
pISSN - 1616-5187
DOI - 10.1002/mabi.201300340
Subject(s) - mesenchymal stem cell , in vivo , chemistry , iron oxide nanoparticles , intracellular , tissue engineering , magnetic resonance imaging , ethylene glycol , ischemia , biophysics , stem cell , nanoparticle , microbiology and biotechnology , biomedical engineering , nanotechnology , materials science , medicine , biochemistry , biology , organic chemistry , radiology
Poly(ethylene glycol)‐coated cross‐linked iron oxide nanoparticles (PCIONs) are developed for therapeutic engineering of mesenchymal stem cells (MSCs) and their monitoring via magnetic resonance (MR) imaging at a time. PCIONs successfully combine with plasmid DNA (pDNA) via ionic interaction. Accordingly, PCION/pDNA complexes mediate superior translocations of vascular endothelial growth factor (VEGF) pDNA into intracellular regions of MSCs under external magnetic field, which significantly elevate production of VEGF from MSCs. Genetically engineered MSCs are also clearly visualized via MR imaging after administration to rat cerebrovascular ischemia models, which enable tracking of MSCs migration from injected sites to injured ischemic area.