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Crosslinked Poly(ethylene glycol) Hydrogels with Degradable Phosphamide Linkers Used as a Drug Carrier in Cancer Therapy
Author(s) -
Zhang Lidong,
Jeong YoungIl,
Zheng Sudan,
Kang Dae Hwan,
Suh Hongsuk,
Kim Il
Publication year - 2014
Publication title -
macromolecular bioscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 105
eISSN - 1616-5195
pISSN - 1616-5187
DOI - 10.1002/mabi.201300327
Subject(s) - chemistry , epichlorohydrin , self healing hydrogels , ethylene glycol , polymer chemistry , diglycidyl ether , ether , drug carrier , drug delivery , glycidyl methacrylate , organic chemistry , cationic polymerization , methacrylate , polymerization , polymer , epoxy , bisphenol a
A series of degradable, water‐swellable PEGs are prepared using crosslinking between primary amines of N , N ′, N ″‐tris(2‐aminoethyl)phosphoric triamide (TAEPT) and diglycidyl ether of epichlorohydrin‐modified PEGs (EMPs). In the crosslinking process, the glycidyl ether is mainly consumed by the –NH 2 of TAEPT and the hydroxyl generated from the opened glycidyl ethers (C–OH), producing degradable phosphonyl‐amide frameworks as crosslinked points, and ether bonds as short branches, respectively. Studies on anticancer drug entrapment, chemoimmunotherapy agent delivery, degradation, and biological cytotoxicity in vitro suggest that the generated hydrogels have great potential as biomaterials in biomedical applications.