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Poly(ethylene glycol) Grafting to Poly(ether imide) Membranes: Influence on Protein Adsorption and Thrombocyte Adhesion
Author(s) -
Neffe Axel T.,
von RuestenLange Maik,
Braune Steffen,
Luetzow Karola,
Roch Toralf,
Richau Klaus,
Jung Friedrich,
Lendlein Andreas
Publication year - 2013
Publication title -
macromolecular bioscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 105
eISSN - 1616-5195
pISSN - 1616-5187
DOI - 10.1002/mabi.201300309
Subject(s) - surface modification , protein adsorption , ethylene glycol , polymer chemistry , peg ratio , grafting , imide , adsorption , ether , membrane , chemistry , adhesion , polymer , chemical engineering , materials science , organic chemistry , biochemistry , finance , engineering , economics
Abstract The chain length and end groups of linear PEG grafted on smooth surfaces is known to influence protein adsorption and thrombocyte adhesion. Here, it is explored whether established structure function relationships can be transferred to application relevant, rough surfaces. Functionalization of poly(ether imide) (PEI) membranes by grafting with monoamino PEG of different chain lengths ( M n = 1 kDa or 10 kDa) and end groups (methoxy or hydroxyl) is proven by spectroscopy, changes of surface hydrophilicity, and surface shielding effects. The surface functionalization does lead to reduction of adsorption of BSA, but not of fibrinogen. The thrombocyte adhesion is increased compared to untreated PEI surfaces. Conclusively, rough instead of smooth polymer or gold surfaces should be investigated as relevant models.