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HPMA Copolymer Conjugates of DOX and Mitomycin C for Combination Therapy: Physicochemical Characterization, Cytotoxic Effects, Combination Index Analysis, and Anti‐ T umor Efficacy
Author(s) -
Kostková Hana,
Etrych Tomáš,
Říhová Blanka,
Kostka Libor,
Starovoytová Larisa,
Kovář Marek,
Ulbrich Karel
Publication year - 2013
Publication title -
macromolecular bioscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 105
eISSN - 1616-5195
pISSN - 1616-5187
DOI - 10.1002/mabi.201300288
Subject(s) - chemistry , conjugate , copolymer , mitomycin c , in vivo , in vitro , drug carrier , drug delivery , polymer , biochemistry , organic chemistry , medicine , mathematical analysis , mathematics , surgery , microbiology and biotechnology , biology
The synthesis, characterization and results of evaluation of the biological behavior of HPMA copolymer conjugates bearing anti‐cancer drugs doxorubicin and mitomycin C are described. Two HPMA copolymer carrier types were synthesized: the linear copolymer and the biodegradable high‐molecular‐weight diblock copolymer containing a degradable disulfide bond. The polymer‐drug conjugates incubated in buffers modeling the intracellular environment released the drugs more rapidly than those incubated in bloodstream conditions. Significant in vitro and in vivo antitumor synergistic activity of the conjugates in the treatment of EL‐4 T‐cell demonstrates their high potential for solid tumor treatment.